Dr. Andrew Sharott MRC Investigator Scientist

Dr. Andrew Sharott graduated in Neuroscience at the University of Nottingham in 2001. He then moved to University College London to study for his Ph.D. in Neurological Studies, with a focus on oscillations in the basal ganglia network, under the supervision of Professor Peter Brown. In 2005, Dr. Sharott moved to the University Medical Centre, Hamburg-Eppendorf (Germany), to undertake postdoctoral work with Professor Andreas Engel. As a Marie Curie Experienced Researcher in Hamburg, Dr. Sharott continued to study oscillations in the basal ganglia, including recordings from patients undergoing the implantation of deep brain stimulation electrodes for the treatment of Parkinson's disease. In summer 2009, Dr. Sharott joined the Unit as an MRC Investigator Scientist to work in the Magill Group. Dr. Sharott's current research is focused on the use of in vivo electrophysiological recording techniques to examine the role of striatal neurons in the healthy and Parkinsonian brain. Email Dr. Andrew Sharott andrew.sharott@pharm.ox.ac.uk Magill Group Page Search for publications (PDFs) Key Research Areas Physiological and anatomical characterisation of striatal neurons. Modulation of striatal neuron activity by the cerebral cortex. Experimental models of Parkinson's disease. Activity of an identified parvalbumin-positive, fast-spiking interneuron in the striatum. (A) The intense firing of the striatal cell in vivo (above) was timed with slow-wave oscillations in the cortex (below). (B) The recorded cell was identified as an interneuron after in vivo labelling with Neurobiotin (red), and was surrounded by other striatal neurons that express parvalbumin (green). The co-localisation of Neurobiotin and parvalbumin in the recorded and labelled interneuron resulted in a yellow signal. Recent Publications before joining the Unit Moll, C.K.E., Sharott, A., Hamel, W., Munchau, A., Buhmann, C., Hidding, U., Zittel, S., Westphal, M., Muller, D., Engel, A.K. (2009) Waking up the brain: a case study of stimulation-induced wakeful unawareness during anaesthesia. Prog Neurobiol 177C:125-145. Sharott, A., Moll, C.K.E., Engler, G., Denker, M., Grün, S., Engel, A.K. (2009) Different subtypes of striatal neurons are selectively modulated by cortical oscillations. J Neurosci 29:4571-4585. Salih, F., Sharott, A., Khatami, R., Trottenberg, T., Schneider, G., Kupsch, A., Brown, P., Grosse, P. (2009) Functional connectivity between motor cortex and globus pallidus in human non-REM sleep. J Physiol 587:1071-1086. Mallet, N., Pogosyan, A., Sharott, A., Csicsvari, J., Bolam, J.P., Brown, P., Magill, P.J. (2008) Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex. J Neurosci 28:4795-4806. Lalo, E., Thobois, S., Sharott, A., Polo, G., Mertens, P., Pogosyan, A., Brown, P. (2008) Patterns of bidirectional communication between cortex and basal ganglia during movement in patients with Parkinson disease. J Neurosci 28:3008-3016. Sharott, A., Grosse, P., Kühn, A.A., Salih, F., Engel, A.K., Kupsch, A., Schneider, G.H., Krauss, J.K., Brown, P. (2008) Is the synchronization between pallidal and muscle activity in primary dystonia due to peripheral afferance or a motor drive? Brain 131:473-484. Magill, P.J., Sharott, A., Bolam, J.P., Brown, P. (2006) Delayed synchronization of activity in cortex and subthalamic nucleus following cortical stimulation in the rat. J Physiol 574:929-946. Magill, P.J., Pogosyan, A., Sharott, A., Csicsvari, J., Bolam, J.P., Brown, P. (2006) Changes in functional connectivity within the rat striato-pallidal axis during global brain activation in vivo. J Neurosci 26:6318-6329.